David G Little Selected Research

Legg-Calve-Perthes Disease (Perthes Disease)

1/2016	The Pathogenesis and Treatment of Legg-Calvé-Perthes Disease.
7/2014	Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs.
9/2012	Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease.
9/2011	Potential for bisphosphonate treatment in Legg-Calve-Perthes disease.
7/2011	Future biologic treatments for Perthes disease.
11/2009	Systemic effects of zoledronic acid in children with traumatic femoral head avascular necrosis and Legg-Calve-Perthes disease.
10/2005	Transient disturbance in physeal morphology is associated with long-term effects of nitrogen-containing bisphosphonates in growing rabbits.
7/2005	Zoledronic acid improves femoral head sphericity in a rat model of perthes disease.

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David G Little Research Topics

Disease

8	Bone Resorption 01/2017 - 07/2005
8	Legg-Calve-Perthes Disease (Perthes Disease) 01/2016 - 07/2005
8	Osteonecrosis (Kienbock's Disease) 04/2015 - 11/2003
6	Osteogenesis Imperfecta (Lobstein Disease) 07/2022 - 10/2005
6	Open Fractures (Compound Fracture) 07/2022 - 02/2013
6	Osteoporosis 11/2011 - 10/2005
5	Closed Fractures (Closed Fracture) 01/2020 - 03/2010
5	Pseudarthrosis (Pseudoarthrosis) 01/2018 - 01/2008
4	Neurofibromatosis 1 (Neurofibromatosis Type I) 10/2021 - 01/2008
4	Infections 01/2020 - 02/2015
4	Osteolysis 06/2017 - 11/2008
3	Wounds and Injuries (Trauma) 01/2018 - 08/2007
3	Fibrosis (Cirrhosis) 01/2018 - 04/2013
2	Muscle Weakness 10/2021 - 01/2018
2	Heterotopic Ossification (Ectopic Ossification) 01/2021 - 07/2014
2	Tibial Fractures (Fracture, Tibial) 12/2019 - 01/2018
2	Muscular Diseases (Myopathy) 10/2018 - 01/2018
2	Body Weight (Weight, Body) 01/2018 - 12/2009
2	Femoral Fractures (Femoral Fracture) 01/2018 - 03/2010
2	Pain (Aches) 09/2013 - 09/2012
2	Congenital Abnormalities (Deformity) 09/2012 - 09/2011
2	Coxa Magna 09/2012 - 09/2011
2	Metabolic Bone Diseases (Osteopenia) 10/2008 - 07/2003
1	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 07/2022
1	Peroneal Neuropathies 07/2022
1	Fatigue 10/2021
1	Weight Loss (Weight Reduction) 07/2021
1	Diastrophic dysplasia 01/2021
1	Multiple Acyl Coenzyme A Dehydrogenase Deficiency 10/2018
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2018
1	Myopathy with Abnormal Lipid Metabolism 01/2018
1	Inflammation (Inflammations) 06/2017
1	Multiple Myeloma 01/2017
1	Slipped Capital Femoral Epiphyses 04/2015
1	Staphylococcal Infections 02/2015
1	Bone Diseases (Bone Disease) 07/2013
1	Bone Fractures (Bone Fracture) 01/2012
1	Necrosis 11/2009
1	Scoliosis 04/2008
1	Acute-Phase Reaction 09/2007
1	Osteopetrosis 06/2005

Drug/Important Bio-Agent (IBA)

21	Diphosphonates (Bisphosphonates)IBA 01/2020 - 06/2005
13	Zoledronic Acid (Zometa)FDA Link 07/2022 - 07/2003
5	Pharmaceutical PreparationsIBA 01/2020 - 06/2005
4	LipidsIBA 01/2020 - 01/2018
4	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2016 - 01/2008
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 02/2015
3	CSA-90IBA 01/2020 - 02/2015
3	Biological ProductsIBA 01/2016 - 07/2011
3	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2012 - 04/2008
3	MineralsIBA 09/2008 - 07/2003
2	alpha2 Subunit Collagen Type IIBA 07/2022 - 01/2019
2	Pamidronate (Aredia)FDA LinkGeneric 01/2020 - 11/2008
2	recombinant human bone morphogenetic protein-2IBA 01/2018 - 02/2015
2	CollagenIBA 01/2018 - 01/2016
2	Parathyroid Hormone (Parathormone)IBA 02/2016 - 03/2010
2	sucrose acetate isobutyrateIBA 01/2016 - 07/2014
2	SteroidsIBA 02/2015 - 09/2013
2	Bone Density Conservation AgentsIBA 07/2013 - 09/2011
2	Anabolic AgentsIBA 09/2012 - 03/2010
1	Growth Hormone (Somatotropin)IBA 01/2022
1	Carnitine (L-Carnitine)FDA LinkGeneric 10/2021
1	Peptides (Polypeptides)IBA 01/2020
1	tdTomatoIBA 12/2019
1	Collagen Type I (Type I Collagen)IBA 01/2019
1	Sirolimus (Rapamycin)FDA Link 01/2019
1	oil red OIBA 01/2018
1	PeptidomimeticsIBA 01/2018
1	mirdametinibIBA 01/2018
1	AntibodiesIBA 01/2018
1	PolymersIBA 06/2017
1	Proteins (Proteins, Gene)FDA Link 01/2017
1	ActRIIA-mIgG2aFc fusion proteinIBA 02/2016
1	ORALIT (ORS)IBA 04/2015
1	artemisinin-naphthoquine combinationIBA 09/2013
1	Pain-FreeIBA 09/2013
1	PlasticsIBA 04/2013
1	Bromodeoxyuridine (BrdU)IBA 01/2012
1	Neuropeptide YIBA 12/2009
1	Polymethyl Methacrylate (Sol)IBA 11/2008

Therapy/Procedure

8	Therapeutics 07/2022 - 08/2007
3	Osteotomy 01/2017 - 03/2010
2	Arthroplasty 09/2013 - 07/2011
2	Distraction Osteogenesis 10/2005 - 07/2003
1	Foot Orthoses 07/2022
1	Euthanasia (Mercy Killing) 07/2021
1	Traction 01/2021
1	Injections 12/2019
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2019
1	Bone Wires 01/2018
1	Decompression 04/2015
1	Analgesia 09/2013
1	Drug Therapy (Chemotherapy) 09/2013
1	Bone Transplantation (Bone Grafting) 07/2011
1	Hip Replacement Arthroplasty (Total Hip Replacement) 11/2008
1	External Fixators 06/2007